Funded Projects

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Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
1R21DA061784-01
Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and Seeking Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA STATE UNIVERSITY OF NEW YORK AT BUFFALO CLARK, STEWART DONALDSON Amherst, NY 2024
NOFO Title: HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-24-064
1UG3DA062088-01
Evaluation of psilocybin as an adjunctive treatment for opioid use disorder in methadone-maintained patients who continue to use illicit opioids Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA NEW YORK UNIVERSITY SCHOOL OF MEDICINE BOGENSCHUTZ, MICHAEL PARKS New York, NY 2024
NOFO Title: Psychedelics Treatment Research in Substance Use Disorder (UG3/UH3 Clinical Trials Optional)
NOFO Number: RFA-DA-25-058
4U01HL150568-02
Effects of experimental sleep disruption and fragmentation on cerebral Mu-opioid receptor function, Mu-opioid receptor agonist analgesia, and abuse liability New Strategies to Prevent and Treat Opioid Addiction Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery NHLBI JOHNS HOPKINS UNIVERSITY SMITH, MICHAEL T Baltimore, MD 2024
NOFO Title: HEAL Initiative: Sleep and Circadian-Dependent Mechanisms Contributing to Opiate Use Disorder (OUD) and Response to Medication Assisted Treatment (MAT) (U01 Clinical Trial Optional)
NOFO Number: RFA-HL-19-029
1R21DA060111-01
The potential benefits of autophagy activator TFEB in opioid use disorder in mice Novel Therapeutic Options for Opioid Use Disorder and Overdose NIDA FLORIDA INTERNATIONAL UNIVERSITY LAKSHMANA, MADEPALLI KRISHNAPPA Miami, FL 2024
NOFO Title: Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)
NOFO Number: RFA-TR-23-010
1OT2DA061065-01
Promoting Wellness among Native Americans in Urban Areas Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA MONTANA CONSORTIUM FOR URBAN INDIAN HEALTH GREEN, BRANDN Helena, MT 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007
1OT2DA061144-01
Development and Implementation of a Community-Led Research Program in the Utah Navajo Health System Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA UTAH NAVAJO HEALTH SYSTEM, INC. HENDY, RICK (contact); KELLEY, ALAN TAYLOR Montezuma Creek, UT 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007
1OT2DA061064-01
Partnering to Achieve Wellness for Native Americans through Indigenous Knowledge (PAWNIK) Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA RAND CORPORATION D'AMICO, ELIZABETH J (contact); JOHNSON, CARRIE Pittsburgh, PA 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain Native Research Resource Network (OT2)
NOFO Number: OTA-23-008
1R21DA059665-01A1
Characterizing Information Needs and Peer Engagement Regarding Medication for Opioid Use Disorder on Social Media Cross-Cutting Research NIDA DARTMOUTH COLLEGE PREUM, SARAH MASUD Hanover, NH 2024
NOFO Title: NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
NOFO Number: PA-20-195
3R24DA057611-03S1
RTI HEAL Harm Reduction Network Coordination Center Translation of Research to Practice for the Treatment of Opioid Addiction Harm Reduction Approaches to Reduce Overdose Deaths NIDA RESEARCH TRIANGLE INSTITUTE OGA, EMMANUEL AJA (contact); CANCE, JESSICA DUNCAN Research Triangle Park, NC 2024
NOFO Title: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
NOFO Number: PA-20-272
3U24DA055330-04S1
Healthy Brain and Child Development National Consortium Data Coordinating Center Enhanced Outcomes for Infants and Children Exposed to Opioids HEALthy Brain and Child Development Study (HBCD) NIDA WASHINGTON UNIVERSITY IN ST. LOUIS SMYSER, CHRISTOPHER DANIEL (contact); DALE, ANDERS M; FAIR, DAMIEN A St. Louis, MO 2024
NOFO Title: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
NOFO Number: PA-20-272
3R01DA057599-01S1
Diversity Supplement for Mining Social Media Big Data for Toxicovigilance Training the Next Generation of Researchers in HEAL NIDA EMORY UNIVERSITY SARKER, ABEED H Atlanta, GA 2024
NOFO Title: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
NOFO Number: PA-23-189
2R42DA056254-02
Development of negative allosteric modulators of the mu-opioid receptor for the management of opioid use disorder Cross-Cutting Research Small Business Programs NIDA ELEVEN THERAPEUTICS CORP TRAYNOR, JOHN R Encinitas, CA 2024
NOFO Title: PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
NOFO Number: PA-23-232
1UG3DA059278-01A1
Development of SBS-226, a MOR agonist / DOR antagonist, for OUD Novel Therapeutic Options for Opioid Use Disorder and Overdose Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose NIDA SPARIAN BIOSCIENCES, INC. REICH, JEFFREY New York, NY 2024
NOFO Title: Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
NOFO Number: PAR-22-200
1UG3DA061616-01
Deep TMS Neuromodulation of Neural Circuits Associated with Stimulant Use Disorder Novel Therapeutic Options for Opioid Use Disorder and Overdose NIDA STANFORD UNIVERSITY PADULA, CLAUDIA B (contact); MADORE, MICHELLE ROSEANN Redwood City, CA 2024
NOFO Title: Device Based Treatments for Substance Use Disorders (UG3/UH3 Clinical Trial Optional)
NOFO Number: PAR-23-253
1R34AA031870-01
Cultivating Recovery: A Pilot Study of Digital Contingency Management for Co-occurring Opioid and Alcohol Use Disorder Translation of Research to Practice for the Treatment of Opioid Addiction NIAAA UNIVERSITY OF MICHIGAN FERNANDEZ, ANNE CHRISTIE (contact); COUGHLIN, LARA NICOLE Ann Arbor, MI 2024
NOFO Title: HEAL Initiative: Developing an Evidence Base for Co-Occurring OUD-AUD Interventions (R34 Clinical Trial Optional)
NOFO Number: RFA-AA-23-006
4U24DA050182-02
HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults New Strategies to Prevent and Treat Opioid Addiction Preventing Opioid Use Disorder NIDA RESEARCH TRIANGLE INSTITUTE RIDENOUR, TY A (contact); GRAHAM, PHILLIP W Research Triangle Park, NC 2024
NOFO Title: HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) Initiative (U24 Clinical Trial Not Allowed)
NOFO Number: RFA-DA-19-034
4R33DA057610-02
Improving pain management and opioid safety through a systemwide, data driven evaluation of the CDC opioid prescribing guideline best practices and the use of Clinical Decision Support Cross-Cutting Research Translating Data 2 Action to Prevent Overdose NIDA UNIVERSITY OF COLORADO DENVER HOPPE, JASON Aurora, CO 2024
NOFO Title: HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-22-051
1R61DA061371-01
A Digital Toolkit to Address Intimate Partner Violence in Opioid Use Disorder Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA MEDICAL UNIVERSITY OF SOUTH CAROLINA JARNECKE, AMBER (contact); SARAIYA, TANYA CHANDRESH Charleston, SC 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
4R33DA059948-02
Workforce and System Change to Treat Adolescent Opioid Use Disorder within Integrated Pediatric Primary Care Translation of Research to Practice for the Treatment of Opioid Addiction Optimizing the Quality, Reach, and Impact of Addiction Services NIDA INDIANA UNIVERSITY INDIANAPOLIS HULVERSHORN, LESLIE A (contact); AALSMA, MATTHEW; ADAMS, ZACHARY WILLIAM Indianapolis, IN 2024
NOFO Title: HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)
NOFO Number: RFA-DA-23-053
1R61DA061831-01
Engaging People Who Use Drugs in Harm Reduction Service Delivery: An Intravention to Reduce Risk of HIV, HCV, Overdose, and Injection-related Infections in Rural Appalachia New Strategies to Prevent and Treat Opioid Addiction NIDA UNIVERSITY OF KENTUCKY YOUNG, APRIL MARIE Lexington, KY 2024
NOFO Title: Rural Community-Centered Drug Misuse Prevention and Harm Reduction Research: Addressing Implementation, Dissemination, and Equity Challenges across the Continuum of Care (R61/R33 Clinical Trial Only)
NOFO Number: RFA-DA-24-036
2U2CDA050097-06
JCOIN Phase II Coordination and Translation Center Translation of Research to Practice for the Treatment of Opioid Addiction Justice Community Opioid Innovation Network (JCOIN) NIDA GEORGE MASON UNIVERSITY TAXMAN, FAYE S (contact); HENDERSON, HOWARD; MOLFENTER, TODD DAVID; NICKEL, JESSICA HULSEY; PETTUS, CARRIE; RUDES, DANIELLE SHELDON Fairfax, VA 2024
NOFO Title: HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Coordination and Translation Center (U2C Clinical Trial Optional)
NOFO Number: RFA-DA-24-069
2UG1HD104254-02
Outcomes of Babies with Opioid Exposure -- Cincinnati site renewal Enhanced Outcomes for Infants and Children Exposed to Opioids Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) NICHD CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER MERHAR, STEPHANIE L Cincinnati, OH 2024
NOFO Title: HEAL Initiative: Limited Competition: Clinical Centers for Completion of the Outcomes of Babies with Opioid Exposure (OBOE) Study (UG1 Clinical Trial Not Allowed)
NOFO Number: RFA-HD-24-014
4UF1MH121954-02
Improving Access and Treatment for Co-occurring Opioid Use Disorders and Mental Illness New Strategies to Prevent and Treat Opioid Addiction Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions NIMH RAND CORPORATION WATKINS, KATHERINE E (contact); KOMAROMY, MIRIAM Santa Monica, CA 2024
NOFO Title: HEAL Initiative: Effectiveness Trials to Optimize, Implement, Scale, and Sustain the Collaborative Care Model for Individuals with Opioid Use Disorders and Mental Health Conditions (U01 Clinical Trial)
NOFO Number: RFA-MH-19-525
3OT2OD037639-01S1
All of Us Pennsylvania (AOU PA) Research Program New Strategies to Prevent and Treat Opioid Addiction OD UNIVERSITY OF PITTSBURGH REIS, STEVEN E (contact); VISWESWARAN, SHYAM Pittsburgh, PA 2024
NOFO Title: All of Us Engagement, Communications, and Enrollment Partnerships
NOFO Number: OTA-22-006
1OT2DA061112-01
Heal(th) From Within: A Research Collaborative to Share our Journeys to Wellness Translation of Research to Practice for the Treatment of Opioid Addiction Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain NIDA ALASKA NATIVE TRIBAL HEALTH CONSORTIUM FORD, TARA (contact); JESSEN, CORNELIA M Anchorage, AK 2024
NOFO Title: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program - Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)
NOFO Number: OTA-23-007