Funded Projects

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Project # Project Title Research Focus Area Research Program Administering IC Institution(s) Investigator(s) Location(s) Year Awarded
3R61AG081034-01S1
Addressing the Chronic Pain Epidemic Among Older Adults in Underserved Community Center: The GetActive+ Study (McDermott-Career Enhancement Supplement) Clinical Research in Pain Management Advancing Health Equity in Pain Management NIA MASSACHUSETTS GENERAL HOSPITAL VRANCEANU, ANA-MARIA (contact); RITCHIE, CHRISTINE S Boston, MA 2023
NOFO Title: Notice of Special Interest (NOSI): Encourage Eligible NIH HEAL Initiative Awardees to Apply for Administrative Supplements to Support Career Enhancement Related to Clinical Research on Pain
NOFO Number: NOT-NS-22-087
Summary:

This project supports a post-doctoral trainee to develop the skills and knowledge needed to pursue a career in clinical pain research. The research will involve optimizing a GetActive mind-body activity program to overcome barriers that prevent disadvantaged older adult populations in community health clinics from access to non-pharmacological pain management strategies. The research will include qualitative analysis of secondary data, a literature review to evaluate methods, and feasibility for establishing a community advisory board for the GetActive project.
1R61CA280979-01
Cancer Pain Management: A Technology-Based Intervention for Asian American Breast Cancer Survivors Clinical Research in Pain Management Advancing Health Equity in Pain Management NCI EMORY UNIVERSITY IM, EUN-OK (contact); CHEE, WONSHIK Atlanta, GA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-037
Summary:

Asian American women who have survived breast cancer and who also have depression are less likely to receive adequate pain treatment due to cultural stigma attached to breast cancer, cultural attitudes about living with pain and symptoms, and language barriers. This project will use a personalizable, technology-based approach to treat cancer pain and depression in Japanese American, Chinese American, and Korean American women who have survived breast cancer. The intervention will accommodate flexibility, accessibility, and anonymity: three factors that have historically hindered effective pain management for this population of breast cancer survivors.
1R61AT012421-01
Integrative Training Program for Pediatric Sickle Cell Pain Clinical Research in Pain Management Advancing Health Equity in Pain Management NCCIH EMORY UNIVERSITY SIL, SOUMITRI Atlanta, GA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-037
Summary:

Sickle cell disease is an inherited blood disorder affecting about 100,000 Americans and more than 20 million people worldwide. It is caused by a mutation in the gene for beta-globin that results in the characteristic sickled shape of red blood cells, life-long severe pain, and shortened lifespan. Optimal treatment of  chronic pain from the condition targets psychological factors contributing to pain, such as pain-related anxiety, fear of movement, and depression. This project will interact with patients and their families to revise and test an existing mind–body and behavioral health treatment tool to target the unique needs and preferences of people managing chronic sickle cell disease pain.
1R61NR020845-01
Equity Using Interventions for Pain and Depression (EQUIPD) Clinical Research in Pain Management Advancing Health Equity in Pain Management NINR INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS MATTHIAS, MARIANNE Indianapolis, IN 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-037
Summary:

Opioid overdose deaths disproportionately affect Black individuals in the United States. While the use of complementary and integrative pain treatments is effective and widely recommended, Black pain patients (especially those who also have depression) face barriers to the use of these approaches. This project will refine, test, and prepare to implement a novel approach to overcoming these treatment barriers. The research will partner with and empower Black patients to find safe, effective pain treatments that best match their values, preferences, and lifestyles.
1R61CA280978-01
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Bone Sarcoma Clinical Research in Pain Management Advancing Health Equity in Pain Management NCI ST. JUDE CHILDREN'S RESEARCH HOSPITAL BRINKMAN, TARA M Memphis, TN 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-037
Summary:

More than half of children and adolescents diagnosed with a type of cancer called bone sarcoma experience pain that interferes with daily life. This project will adapt an evidence-based cognitive behavioral therapy mobile app for use with Black and Hispanic adolescents who disproportionately experience pain from this cancer, putting them at risk for opioid misuse. Once fully adapted, this therapy will be paired with a remotely delivered brain stimulation treatment (transcranial direct current stimulation). This research will also examine the impact of patient-reported conditions such as depression, anxiety, and sleep problems, as well as of various social determinants of health, on pain.
1R61AT012309-01
Partners for Pain & Wellbeing Equity: A Randomized Trial of Community Supported Complementary and Integrative Health Self-Management for Back Pain Clinical Research in Pain Management Advancing Health Equity in Pain Management NCCIH UNIVERSITY OF MINNESOTA EVANS, RONI L; LENINGER, BRENT Minneapolis, MN 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002
Summary:

Back pain, including low back and neck pain, is one of the most prevalent and disabling pain disorders. Treatment requires ongoing self-management, but most healthcare systems do not support self-care and instead focus on costly, provider-dependent therapies that remain inaccessible to many Black and Hispanic Americans and individuals with less education and income. This project will address these health disparities by developing a personalized self-management treatment program that includes pain education, mindfulness, cognitive behavioral therapy, and exercise – and make it available in community settings.
1R61MD018333-01
Group-Based Integrative Pain Management: A Multi-Level Approach to Address Intersectional Stigma and Social Isolation in Diverse Primary Care Safety Net Patients with Chronic Pain Clinical Research in Pain Management Advancing Health Equity in Pain Management NIMHD University of California, San Francisco CHAO, MARIA San Francisco, CA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

Many barriers exist in primary care offices where socioeconomically disadvantaged patients are most often treated. This project seeks to address chronic pain disparities that affect racially diverse, socioeconomically disadvantaged individuals. The study aims to optimize multimodal pain management in primary care clinics for low-income populations. This study includes two group-based models: integrative group medical visits and group acupuncture. These two interventions will be compared to typical treatment to measure both pain interference and social isolation. National experts and patient stakeholders will refine and optimize the design of the study with English- or Spanish-speaking patients with chronic pain in two primary care clinics for low-income populations.
1R61AG081034-01
Addressing the Chronic Pain Epidemic among Older Adults in Underserved Community Center; The GetActive+ Study Clinical Research in Pain Management Advancing Health Equity in Pain Management NIA Massachusetts General Hospital VRANCEANU, ANA-MARIA (contact); RITCHIE, CHRISTINE S Boston, MA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

This research project will include focus group interviews with clinicians, patients, medical interpreters, and healthcare administrators to identify barriers and facilitators to administering the GetActive+ intervention in a group visit at a clinic for older adults with chronic pain, to inform development of a therapy manual. The project will then test the GetActive+ intervention for changes in physical function immediately post-intervention and after 6 months, as well as for changes in pain, sleep, depression, and anxiety at both time points. This research will also assess feasibility, acceptability, fidelity, and adoption of the intervention with patients, providers, and healthcare staff. 
1R61MH132249-01
Latinx Children and Surgery Clinical Research in Pain Management Advancing Health Equity in Pain Management NIMH University of California, Irvine KAIN, ZEEV Irvine, CA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

Both pain experience and treatment response are determined by a variety of factors, including race and ethnicity. Inequities in access to healthcare and pain treatment affect patients from minority populations, such as Hispanic/Latino populations of all age groups. This study will develop and test an online intervention—Web-based Tailored Intervention for Preparation of Parents and Children for Outpatient Surgery (L-WebTIPS)—tailored for Latino families of children having outpatient surgeries. The intervention aims to lower child and family anxiety before surgery as well as to reduce post-surgical pain by enhancing parent self-efficacy and behavioral pain coping strategies. After an exploratory phase to assess usability and acceptability of the intervention, the study will evaluate the impact of L-WebTIPS on child pre-surgery anxiety and post-surgery pain as well assess other child and parent outcomes.
1R61CA278594-01
Achieving Equity through SocioCulturally-Informed, Digitally-Enabled Cancer Pain managemeNT" (ASCENT) Clinical Trial Clinical Research in Pain Management Advancing Health Equity in Pain Management NCI Mayo Clinic CHEVILLE, ANDREA LYNNE (contact); DOUBENI, CHYKE ABADAMA Rochester, MN 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

Cancer pain treatment disparities are associated with a decreased ability to tolerate treatment, as well as increased rates of disability, unemployment, institutionalization, and early death. The Achieving Equity through SocioCulturally-informed, Digitally-Enabled Cancer Pain managemeNT (ASCENT) clinical trial will test whether a novel digitally enabled, collaborative approach to team-based pain management can improve clinical outcomes and reduce long-standing and devastating disparities among rural dwelling and Hispanic/Latinx cancer survivors. A major focus of the randomized, effectiveness clinical trial is to test the hypothesis that the ASCENT intervention will reduce pain and unplanned healthcare use, while improving function, mood, sleep, and quality of life.
1R61NS129050-01
Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Tailored Digital Tools, Telehealth Coaching, and Primary Care Coordination Clinical Research in Pain Management Advancing Health Equity in Pain Management NINDS University of California, San Francisco SATTERFIELD, JASON M San Francisco, CA 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

There is a need to improve access to treatments and address the stigma, bias, and mistrust that harm and isolate people with chronic pain, especially those from ethnic and racial minority populations. The Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE) Chronic Pain (CP) intervention blends cognitive-behavioral therapy, physical therapy, mindfulness, and pain education, and is delivered by a trilingual mobile app and supported by a telehealth pain coach who coordinates with doctors. The coach will collect and summarize patient reports on pain, depression, anxiety, substance use, and social factors, and share them with healthcare providers. In this project, researchers will create the digital tool and coaching protocol, develop educational and implementation strategies for healthcare providers, and conduct a pilot test. They will then perform a randomized clinical trial to compare INSPIRE to current treatment, analyze its effects, and evaluate outcomes.
1R61DK135406-01
PAINED: Project Addressing Inequities in the Emergency Department Clinical Research in Pain Management Advancing Health Equity in Pain Management NIDDK Children's Research Institute GOYAL, MONIKA KUMARI Washington, DC 2022
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: NS22-002
Summary:

Clinician bias causes inequities in healthcare, and interventions are needed to mitigate and eradicate this bias. This project aims to develop and test the impact of two interventions on overcoming clinician implicit bias in the management of pain for children from ethnic minorities treated in the emergency department. The study will include pediatric patients from under-represented minority groups with pain from long-bone fractures or acute appendicitis who are cared for by racially and ethnically diverse caregivers. Researchers will use stakeholder-informed approaches to establish quality of care metrics and then use clinician audit and feedback as well as data from electronic health records to quantify evidence of bias.      
4R33AG081034-02
Addressing the chronic pain epidemic among older adults in underserved community center; The GetActive+ study. Clinical Research in Pain Management Advancing Health Equity in Pain Management NIA MASSACHUSETTS GENERAL HOSPITAL VRANCEANU, ANA-MARIA (contact); RITCHIE, CHRISTINE S Boston, MA 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002
4R33MH132249-02
Latinx Children and Surgery Clinical Research in Pain Management Advancing Health Equity in Pain Management NIMH UNIVERSITY OF CALIFORNIA IRVINE KAIN, ZEEV Irvine, CA 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002
4R33DK135406-02
PAINED: Project Addressing INequities in the Emergency Department Clinical Research in Pain Management Advancing Health Equity in Pain Management NIDDK CHILDREN’S RESEARCH INSTITUTE GOYAL, MONIKA KUMARI Washington, DC 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002
4R33NS129050-02
Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Tailored digital tools, telehealth coaching, and primary care coordination Clinical Research in Pain Management Advancing Health Equity in Pain Management NINDS UNIVERSITY OF CALIFORNIA SAN FRANCISCO SATTERFIELD, JASON M San Francisco, CA 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002
4R33NR020845-02
Equity Using Interventions for Pain and Depression (EQUIPD) Clinical Research in Pain Management Advancing Health Equity in Pain Management NINR INDIANA UNIVERSITY MATTHIAS, MARIANNE Indianapolis, IN 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain and Comorbidities (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-037
4R33MD018333-02
Group-based Integrative Pain Management: A multi-level approach to address intersectional stigma and social isolation in diverse primary care safety net patients with chronic pain Clinical Research in Pain Management Advancing Health Equity in Pain Management NIMHD UNIVERSITY OF CALIFORNIA SAN FRANCISCO CHAO, MARIA T San Francisco, CA 2024
NOFO Title: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
NOFO Number: RFA-NS-22-002